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multilayer three-dimensional (3d) scaffolds  (BioMimetic Therapeutics)

 
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    BioMimetic Therapeutics multilayer three-dimensional (3d) scaffolds
    In <t>vivo</t> <t>osteochondral</t> regeneration capacity of gradient hydrogels. A) Gross images of the regenerated osteochondral tissues in the Control, UGel, HGGel, CGGgel, and CGGgel + MF groups, for 6 and 12 weeks, and B) ICRS macroscopic scores for gross observations. C) Surface geomorphologies of the regenerated osteochondral tissues at 12th week, and D) quantification of the representative roughness parameter Ra. E) Reconstructed <t>3D</t> micro-CT images of the regenerated osteochondral tissues for 12 weeks. Analysis of micro-CT images showing F) the newly formed bone volume fraction (BV/TV), G) trabeculae number (Tb.N), and H) trabecular separation (Tb.Sp). I) Histological images of H&E and SO/FG staining of the regenerated osteochondral tissues for 6 and 12 weeks. J) Wakitani's scores and I) Seller's scores for histological evaluation. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001, n = 4.
    Multilayer Three Dimensional (3d) Scaffolds, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/three-dimensional+scaffold/3d+scaffolds/pmc11985089-16-3-0
    Average 90 stars, based on 1 article reviews
    multilayer three-dimensional (3d) scaffolds - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Continuous mechanical-gradient hydrogel with on-demand distributed Mn 2+ /Mg-doped hydroxyapatite@Fe 3 O 4 for functional osteochondral regeneration"

    Article Title: Continuous mechanical-gradient hydrogel with on-demand distributed Mn 2+ /Mg-doped hydroxyapatite@Fe 3 O 4 for functional osteochondral regeneration

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2025.03.013

    In vivo osteochondral regeneration capacity of gradient hydrogels. A) Gross images of the regenerated osteochondral tissues in the Control, UGel, HGGel, CGGgel, and CGGgel + MF groups, for 6 and 12 weeks, and B) ICRS macroscopic scores for gross observations. C) Surface geomorphologies of the regenerated osteochondral tissues at 12th week, and D) quantification of the representative roughness parameter Ra. E) Reconstructed 3D micro-CT images of the regenerated osteochondral tissues for 12 weeks. Analysis of micro-CT images showing F) the newly formed bone volume fraction (BV/TV), G) trabeculae number (Tb.N), and H) trabecular separation (Tb.Sp). I) Histological images of H&E and SO/FG staining of the regenerated osteochondral tissues for 6 and 12 weeks. J) Wakitani's scores and I) Seller's scores for histological evaluation. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001, n = 4.
    Figure Legend Snippet: In vivo osteochondral regeneration capacity of gradient hydrogels. A) Gross images of the regenerated osteochondral tissues in the Control, UGel, HGGel, CGGgel, and CGGgel + MF groups, for 6 and 12 weeks, and B) ICRS macroscopic scores for gross observations. C) Surface geomorphologies of the regenerated osteochondral tissues at 12th week, and D) quantification of the representative roughness parameter Ra. E) Reconstructed 3D micro-CT images of the regenerated osteochondral tissues for 12 weeks. Analysis of micro-CT images showing F) the newly formed bone volume fraction (BV/TV), G) trabeculae number (Tb.N), and H) trabecular separation (Tb.Sp). I) Histological images of H&E and SO/FG staining of the regenerated osteochondral tissues for 6 and 12 weeks. J) Wakitani's scores and I) Seller's scores for histological evaluation. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001, n = 4.

    Techniques Used: In Vivo, Control, Micro-CT, Staining

    Related Articles

    other:

    Article Title: Effects of Phenolics on the Physicochemical and Structural Properties of Collagen Hydrogel.
    Article Snippet: ; Attenburrow, G. Cross-Linking of Extruded Collagen Fibers—A Biomimetic Three-Dimensional Scaffold for Tissue Engineering Applications.

    Article Title: Microfluidic extrusion
    Article Snippet: Zeugolis, D. I., Paul, G. R. and Attenburrow, G. (2009) ‘Cross-linking of extruded collagen fibers-A biomimetic three-dimensional scaffold for tissue engineering applications’, Journal of Biomedical Materials Research—Part A, 89(4), pp.

    Article Title: Microfluidic extrusion
    Article Snippet: Zeugolis, D. I., Paul, G. R. and Attenburrow, G. (2009) ‘Cross-linking of extruded collagen fibers—A biomimetic three-dimensional scaffold for tissue engineering applications’, Journal of Biomedical Materials Research—Part A, 89(4), pp.

    Article Title: Bioglass incorporation improves mechanical properties and enhances cell-mediated mineralization on electrochemically aligned collagen threads.
    Article Snippet: Bone tissue engineering mandates the development of a functional scaffold that mimics the physicochemical properties of native bone.. Bioglass 45S5 (BG) is a highly bioactive material known to augment bone formation and restoration.. Hybrid scaffolds fabricated using collagen type I and BG resemble the organic and inorganic composition of the bone extracellular matrix and hence have been extensively investigated for bone tissue engineering applications.



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    Image Search Results


    In vivo osteochondral regeneration capacity of gradient hydrogels. A) Gross images of the regenerated osteochondral tissues in the Control, UGel, HGGel, CGGgel, and CGGgel + MF groups, for 6 and 12 weeks, and B) ICRS macroscopic scores for gross observations. C) Surface geomorphologies of the regenerated osteochondral tissues at 12th week, and D) quantification of the representative roughness parameter Ra. E) Reconstructed 3D micro-CT images of the regenerated osteochondral tissues for 12 weeks. Analysis of micro-CT images showing F) the newly formed bone volume fraction (BV/TV), G) trabeculae number (Tb.N), and H) trabecular separation (Tb.Sp). I) Histological images of H&E and SO/FG staining of the regenerated osteochondral tissues for 6 and 12 weeks. J) Wakitani's scores and I) Seller's scores for histological evaluation. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001, n = 4.

    Journal: Bioactive Materials

    Article Title: Continuous mechanical-gradient hydrogel with on-demand distributed Mn 2+ /Mg-doped hydroxyapatite@Fe 3 O 4 for functional osteochondral regeneration

    doi: 10.1016/j.bioactmat.2025.03.013

    Figure Lengend Snippet: In vivo osteochondral regeneration capacity of gradient hydrogels. A) Gross images of the regenerated osteochondral tissues in the Control, UGel, HGGel, CGGgel, and CGGgel + MF groups, for 6 and 12 weeks, and B) ICRS macroscopic scores for gross observations. C) Surface geomorphologies of the regenerated osteochondral tissues at 12th week, and D) quantification of the representative roughness parameter Ra. E) Reconstructed 3D micro-CT images of the regenerated osteochondral tissues for 12 weeks. Analysis of micro-CT images showing F) the newly formed bone volume fraction (BV/TV), G) trabeculae number (Tb.N), and H) trabecular separation (Tb.Sp). I) Histological images of H&E and SO/FG staining of the regenerated osteochondral tissues for 6 and 12 weeks. J) Wakitani's scores and I) Seller's scores for histological evaluation. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001, n = 4.

    Article Snippet: Biomimetic multilayer three-dimensional (3D) scaffolds are often designed to replicate the hierarchical structure of natural osteochondral tissue for the repair and regeneration of cartilage defects [ ].

    Techniques: In Vivo, Control, Micro-CT, Staining